Summary
- A Ph.D. student in cellular and molecular biology.
- A dedicated and meticulous researcher with over a decade of practical experience in gene association studies, particularly focused on diabetes and cancer.
- Passionate about expanding her research and knowledge in cancer biology and related areas, especially precision medicine, and pharmacogenomics.
Education
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Oct 2020-Current Ph.D. in Cellular and Molecular Biology
Tehran Medical Sciences, Islamic Azad University (IAUTMU), Tehran, Iran
Graduation Date: Ongoing
Thesis title: “Pharmacogenomic Profile Analysis of Sixteen Drug Categories in the Iranian Population”.
Primary Advisor: Prof. Mandana Hasanzad
Secondary Advisor: Prof. Shekoufeh Nikfar
Objectives: Identifying the genetic variations with high allele frequency in the Iranian population to recommend for use in the pre-emptive PGx testing in the clinical setting.
(CYP2D6, CYP2C19, CYP2C9, DPYD, TPMT, NUDT15, SLOC1B1, and UGT1A1) (as per CPIC guidelines) related to 16 drug categories (95 drugs)
Population: 1142 healthy unrelated Individuals from different parts of the country
Samples: Saliva
Clinical sites (Country): Tehran University of Medical Sciences (Iran)
Platform: The Infinium Global Screening Array-24 BeadChip
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Feb 2014-Aug 2016 M.Sc. in Cellular and Molecular Biology
Tehran Medical Sciences, Islamic Azad University (IAUTMU), Tehran, Iran
Gratuation Date: Aug 2016
*M.Sc. degree is offered between 1-2 years long in Iran and is usually followed by writing a scientific thesis at the end of your academic studies. The award of the credential typically requires 28 to 45 credits, depending on the program, with an overall GPA of 14 out of 20 or better, and the completion of a thesis.
Thesis Title: “Evaluation of endothelial growth factor A (VEGFA) genetic variant and expression in endometriosis”
Advisor: Prof. Mahsa Mohammad Amoli
Clinical sites (Country): Tehran University of Medical Sciences (Iran)
Study design: Case-control study
Platform: Real-Time PCR
GPA: 19.61 out of 20
Award: Selected chief student
Publications:
Feb 2009-Feb 2013 B.S. in Cellular and Molecular Biology-Genetics
Department of Genetics, Tehran Medical Sciences, Islamic Azad University (IAUTMU), Tehran, Iran
Gratuation Date: Feb 2013
*B.Sc. degree usually takes a minimum of four years of full-time study to complete in Iran and requires at least 130 credits. Students must achieve a minimum grade point average of 12 out of 20 to earn the degree.
GPA: 17.29 out of 20
Award: The distinctive student of the year (A talented student)
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Work Experience
Since Aug 2017
“Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran“
Responsibilities: I hold the responsibility to manage projects and the monitor students.
Position: Full-Time working as a Research Associate.
Supervisors: My practice is supervised by Prof. Mandana Hasanzad PhD, molecular genetics and Pro. Shekoufeh Nikfar PharmD, MPH, PhD. of pharmacoeconomics.
Feb 2, 2020
Amazon Prime debuts
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Jan 31, 2021
Amazon acquires Audible
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“Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran“
Since Aug 2017
Responsibilities: I hold the responsibility to manage projects and the monitor students.
Position: Full-Time working as a Research Associate.
Supervisors: My practice is supervised by Prof. Mandana Hasanzad PhD, molecular genetics and Pro. Shekoufeh Nikfar PharmD, MPH, PhD. of pharmacoeconomics.
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“Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran”
Mar 2015-Sep 2017
Responsibilities: I collaborated to some projects and labaratory process.
Position: Part-time, Research Assistant.
Supervisors: My practice is supervised by Prof. Ramin Heshmat M.D., Ph.D. of epidemiology, and Dr. Fatemeh Khatami Ph.D. molecular medicine.
“Immunogenetic Department, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran“
May 2013-Aug 2017
Responsibilities: I collaborated to some projects and labaratory process.
Position: Part-time, Research assistant and laboratory expert.
Supervisors: My practice is supervised by Prof. Mahsa Mohammad Amoli M.D., Ph.D. of human genetics.
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“Life and Me“
Nov 2017-Dec 2018
Responsibilities: I collaborated to genetic department.
Position: Part-time, genetic expert.
Supervisors: My practice is supervised by Prof. Mandana Hasanzad PhD, molecular genetics, the head of genetic department.
Publications
- Articles
- Abstracts
- Books
- Patrinos GP, Sarhangi N, Sarrami B, Khodayari N, Larijani B, Hasanzad M. Using ChatGPT to predict the future of personalized medicine. The Pharmacogenomics Journal. 2023 Sep 19:1-7. https://doi.org/10.1038/s41397-023-00316-9
- Hasanzad M, Sarhangi N, Naghavi A, Ghavimehr E, Khatami F, Ehsani Chimeh S, Larijani B, Aghaei Meybodi HR. Genomic medicine on the frontier of precision medicine. J Diabetes Metab Disords. 2022 Jun;21(1):853-61. https://doi.org/10.1007/s40200-021-00880-6
- Sarhangi N, Hajjari SH, Heydari SF, et al. Breast cancer in the era of precision medicine. Mol Biol Rep. 2022 Oct;49(10):10023-10037. https://doi.org/10.1007/s11033-022-07571-2
- Hasanzad M, Aghaei Meybodi HR, Sarhangi N, Larijani B. Artificial intelligence perspective in the future of endocrine diseases. J Diabetes Metab Disords. 2022 Jun;21(1):971-8. https://doi.org/10.1007/s40200-021-00949-2
- Taleb A, Afshari M, Samzadeh M, Sarhangi N, et al. Influence of cytotoxic T lymphocyte antigen 4 genetic variants on acute rejection in kidney transplant patients: precision medicine perspective. J Diabetes Metab Disords. 2022:1-7. https://doi.org/10.1007/s40200-021-00936-7
- Dianatshoar D, Alidaee T, Sarhangi N, et al. Effects of the TCF7L2 and KCNQ1 common variant on sulfonylurea response in type 2 diabetes mellitus patients: a preliminary pharmacogenetic study. J Diabetes Metab Disords. 2022 Jan 11:1-7. https://doi.org/10.1007/s40200-021-00947-4
- Babaei M, Sarhangi N, Shahrabi-Farahani M, et al. Investigation of TGF-β1 gene variant and expression in a group of Iranian women with endometriosis. Arch Gynecol Obstet. 2021 Sep 3. https://doi.org/10.1007/s00404-021-06195-4 (Corresponding author)
- Didari E, Sarhangi N, Afshari M, et al. A pharmacogenetic pilot study of CYP2C9 common genetic variant and sulfonylureas therapeutic response in type 2 diabetes mellitus patients. J Diabetes Metab Disords. 2021 Dec;20:1513-9. https://doi.org/10.1007/s40200-021-00894-0
- Hasanzad M, Sarhangi N, Ehsani Chimeh S, et al. Precision medicine journey through omics approach. J Diabetes Metab Disords. 2021 Nov 24:1-8. https://doi.org/10.1007/s40200-021-00913-0
- Shirvani Rad S, Nikkhah A, Orvatinia M, Ejtahed HS, Sarhangi N, Jamaldini SH, Khodayari N, Aghaei Meybodi HR, Hasanzad M. Gut microbiota: a perspective of precision medicine in endocrine disorders. J Diabetes Metab Disords. 2020 Jul 23. https://doi.org/10.1007/s40200-020-00593-2
- Hasanzad M, Sarhangi N, Nikfar S, et al. A narrative review of current trends in liraglutide: insights into the unmet needs in the management of type 2 diabetes and obesity. J Diabetes Metab Disords. 2020 Aug 28:1-0. https://doi.org/10.1007/s40200-020-00619-9
- Tarki SE, Far IS, Aminimoghaddam S, Fooladi B, Sarhangi N, et al. Investigating the association of matrix metalloproteinase-2 gene variants with endometriosis in an Iranian population. Eur J Obstet Gynecol Reprod Biol. 2021 Mar 1;258:353-7. https://doi.org/10.1016/j.ejogrb.2020.12.013
- Hasanzad M, Hassani Doabsari M, Rahbaran M, Banihashemi P, Fazeli F, Ganji M, Manavi Nameghi S, Sarhangi N, Nikfar S, Aghaei Meybodi HR. A systematic review of miRNAs as biomarkers in osteoporosis disease. J Diabetes Metab Disords. 2021 Dec;20(2):1391-406. https://doi.org/10.1007/s40200-021-00873-5
- Hashemian L, Sarhangi N, Afshari M, Aghaei Meybodi HR, Hasanzad M. The role of the PPARG (Pro12Ala) common genetic variant on type 2 diabetes mellitus risk. J Diabetes Metab Disords. 2021 Dec;20(2):1385-90. https://doi.org/10.1007/s40200-021-00872-6
- Jamalizadeh M, Hasanzad M, Sarhangi N, Sharifi F, Nasli-Esfahani E, Larijani B. Pilot study in pharmacogenomic management of empagliflozin in type 2 diabetes mellitus patients. J Diabetes Metab Disords. 2021 Dec;20(2):1407-13. https://doi.org/10.1007/s40200-021-00874-4
- Sarhangi N, Sharifi F, Hashemian L, et al. PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis. Sci Rep. 2020 Jul 29;10(1):1-8. https://doi.org/10.1038/s41598-020-69363-7
- Banihashemi P, Meybodi HR, Afshari M, Sarhangi N, Hasanzad M. Association analysis of HHEX gene variant with type 2 diabetes risk. International Journal of Diabetes in Developing Countries. 2020 Sep 18:1-5. https://doi.org/10.1007/s13410-020-00870-z
- Saki N, Sarhangi N, Afshari M, Bandarian F, Meybodi HR, Hasanzad M. MTNR1B common genetic variant is associated with type 2 diabetes mellitus risk. Gene Rep. 2020 Apr 28:100695.
- Khooshemehri P, Jamaldini SH, Ziaee SA, Afshari M, Sattari M, Narouie B, Sotoudeh M, Montazeri V, Sarhangi N, Hasanzad M. Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer. Urology Journal. 2020 May 16;17(3):271-5. https://doi.org/10.22037/uj.v0i0.5051
- Rashidi BH, Sarhangi N, Aminimoghaddam S, et al. Association of vascular endothelial growth factor (VEGF) Gene polymorphisms and expression with the risk of endometriosis: a case–control study. Mol Biol Rep. 2019 Jun 1;46(3):3445-50. https://doi.org/10.1007/s11033-019-04807-6 Co-first author
- Sarhangi N, Mohseni S, Aminimoghaddam S, Rashidi BH, Haghollahi F, Qorbani M, Amoli MM, Shahrabi-Farahani M. The Association Analysis of Vascular Endothelial Growth Factor-2549 Insertion/Deletion Variant and Endometriosis Risk. Int J Mol Cell Med. 2019;8(Suppl1):63. https://doi.org/10.22088/IJMCM.BUMS.8.2.63
- Motamedi RK, Sarhangi N, Afshari M, et al. Kallikarein‐related peptidase 3 common genetic variant and the risk of prostate cancer. J Cell Biochem. 2019 Sep;120(9):14822-30. https://doi.org/10.1002/jcb.28743
- Hasanzad M, Sarhangi N, Meybodi HR, et al. Precision medicine in non communicable diseases. Int J Mol Cell Med. 2019;8(Suppl1):1. https://doi.org/10.22088/IJMCM.BUMS.8.2.1
- Azizi SM, Sarhangi N, Afshari M, Abbasi D, Meybodi HR, Hasanzad M. Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk. Int J Mol Cell Med. 2019;8(Suppl1):56. https://doi.org/10.22088/IJMCM.BUMS.8.2.56
- Erfani T, Sarhangi N, Afshari M, et al. KCNQ1 common genetic variant and type 2 diabetes mellitus risk. J Diabetes Metab Disords. 2019 Dec 8:1-5. https://doi.org/10.1007/s40200-019-00473-4
- Afshardoost S, Sarhangi N, Afshari M, et al. The influence of a genetic variant in the KCNQ1 gene on type 2 diabetes mellitus development. Gene Rep. 2019 Dec 1;17:100529.
- Sarhangi N, Khatami F, Keshtkar A, Heshmat R, Atlasi R, Mohammadamoli M. The role of mitochondrial DNA (mtDNA) in the development of diabetic retinopathy (DR): A systematic review. Med Hypothesis Discov Innov Ophthalmol. 2017;6(2):30.
- Sarhangi N, Rahbar F, Hasanzad M. Pharmacogenomic approach in type 2 diabetes treatment. Koomesh. 2022 Apr 10;24(2):237-44.
- Sarhangi N, Sharifi F, Nikfar S, Hasanzad M. Pharmacogenomics approach in psychiatry disorders. Koomesh. 2022 Apr 10;24(2):255-66.
- Rahmani N, Minuchehr Z, Bambai B, Sarhangi N, Allahyari Fard N. Evaluation of vitamins diversity produced by probiotics in the microbiome and introduction of selected species. Koomesh. 2022 Apr 10;24(2):267-75.
- Manavi Nameghi S, Hasanzad M, Sarhangi N. Genetic Variant of GIPR gene and the risk of type 2 diabetes. Diabetes Res Clin Pract. 2022 Apr; 186 (Suppl1): 109459. https://doi.org/10.1016/j.diabres.2022.109459
- Sarhangi N, Aghaei Meybodi HR, Nikfar S, Hasanzad M. COVID-19: A Review of Treatment Strategies and Candidate Vaccines. Scientific Journal of Kurdistan University of Medical Sciences. 2021 Nov 10;26(5):126-50.
- Shirvanirad S, Nikkhah A, Orvatinia MM, Ejtahed HS, Sarhangi N, Aghaei Meybodi HR, Hasanzad M. The microbiome in precision medicine: A new approach to cancer treatment. Journal of Mazandaran University of Medical Sciences. 2021 Jan 10;30(193):21-37.
- Bozorgnejad N, Aghaei Meybodi HR, Afshari M, Sarhangi N, Hasanzad M. Association Analysis Between Rs10830962 Variant Of Mtnr1b Gene And Type 2 Diabetes Mellitus Risk. Iranian Journal of Diabetes and Metabolism. 2020 Feb 10;19(3):114-22.
- Precision Medicine in Clinical Practice; publication by Springer Nature
- Liquid Biopsy: Circulating Tumor Cells & Free Gene Fragments (Persian)
- Oncolytic Viruses: novel approaches in cancer therapy (Persian)
Congress
- Poster in the IDF Congress 2019, Busan, Korea, 2-6 December, By title: MNTR1B genetic variant association analysis and risk of type 2 diabetes mellitus.
- Presentation in 8th IRHRC Annual Meeting on Reproductive and Infertility Updates, December, 16-18, 2015, Tehran–Iran, By title: -2578 A/C Polymorphism in the Vascular Endothelial Growth Factor Gene and the Risk of Endometriosis in an Iranian Population.
- Poster in 9th Molecular Immunology & Immunogenetics Congress, March 08-09, 2018 in London–UK,By title: Association of Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms and Expression with the risk of Endometriosis in Iran.
- Poster in 1th International Congress of Iranian Personalized Medicine, February, 2017 , Tehran–Iran,By title: Circulating Tumor Cells (CTCs) count and Personalized Management of Breast Cancer: A Systematic Review
- Poster in the 17th Royan International Congress on Reproductive Biomedicine, August 31-September 2, 2016, Tehran–Iran, By title: Molecular Analysis of VEGF -2549 Ins/Del and Endometriosis Risk in Iranian Women.
- Poster in 2th International Congress on Reproduction (ISERB), May 18-20, 2016, Tehran–Iran, By title: Molecular Analysis of VEGF in Susceptibility to Endometriosis in Iranian Women.
- Attending in 1th personalized medicine symposium, December 14-15, 2017, Tehran–Iran.
- Attending in 10th Royan International Congress on Stem Cell Biology & Technology, September 3-5, 2014, Tehran–Iran.
Academic Skills
- Experience in research management and running experiments
- Expert in research design, database searches, and literature reviews
- Expert in molecular techniques containing primer design, DNA and RNA Extraction, PCR-RFLP, cDNA Synthesis, Real-Time PCR, Electrophoresis (SDS-PAGE, Agarose)
- Sufficient experience in bioinformatics work:
- PGx Databases including PhramVar, PGKB, and CPIC
- Software including R Package, Prism6, REST 2009, Stata, Endnote, SPSS, and Chromass DNA Sequencing
- Databases including UCSC, Ensembl, NCBI, HGNC, VarSome, EMBL-EBI, and SNPedia
- Operation system: Linux (basic knowledge)
- Familiar with the GMP (good manufacturing practice) principles
- Collaboration in the design of the primer design website
- Expert in systematic review and meta-analysis
Services
- Manuscript reviewer in some international journals.
- Executive secretary at “Iran’s 1st National Independent Conference of Pharmacogenomics” (16 January 2020).