Category: Article

Abstract Purpose: Endometriosis is defined as a common gynecologic and inflammatory disease. Transforming growth factor-beta 1 (TGF-β1) gene and its protein level might play a role in the pathogenesis of endometriosis. The present study aimed for the first time to assess the associations between endometriosis risk and −509 C/T (rs1800469) variant of the TGF-β1 gene…

Abstract Kallikarein-related peptidase 3 (KLK3) gene polymorphisms seem to play a role in susceptibility to prostate cancer (PC). The purpose of this study was to investigate the association between rs2735839 polymorphism of the KLK3 gene and the risk of PC in an Iranian population. In this case-control study, rs2735839 was genotyped in 532 patients with…

Abstract Endometriosis is a polygenic and multifactorial gynecology situation which might be associated with angiogenesis. In the current study, we assess the role of vascular endothelial growth factor (VEGF) −2578A/C, and +936C/T polymorphisms in susceptibility to endometriosis and checking the expression of VEGF mRNA in eutopic tissue of endometrium with and without endometriosis. The study…

Abstract It has been well established that understanding the underlying heterogeneity of numerous complex disease process needs newstrategies that present in precision medicine for prediction, prevention, and personalized treatment strategies. This approachmust be tailored for each individual’s unique omics that lead to personalized management of disease. The correlation betweendifferent omics data should be considered in…

Abstract Genomic medicine has created a great deal of hope since the completion of the Human Genome Project (HGP). Genomic medicine promises disease prevention and early diagnosis in the context of precision medicine. Precision medicine as a scientific discipline has introduced as an evolution in medicine. The rapid growth of high-development technologies permits the assessment…

Abstract Personalized medicine is a novel frontier in health care that is based on each person’s unique genetic makeup. It represents an exciting opportunity to improve the future of individualized health care for all individuals. Pharmacogenomics, as the main part of personalized medicine, aims to optimize and create a more targeted treatment approach based on…

Abstract Type 2 diabetes mellitus (T2DM) is a complex disease caused by the interaction between genetic and environmental factors. A growing number of evidence suggests that the peroxisome proliferator-activated receptor gamma (PPARG) gene plays a major role in T2DM development. Meta-analysis of genetic association studies is an efficient tool to gain a better understanding of…

Abstract Breast cancer is a heterogeneous disorder with different molecular subtypes and biological characteristics for which there are diverse therapeutic approaches and clinical outcomes specific to any molecular subtype. It is a global health concern due to a lack of efficient therapy regimens that might be used for all disease subtypes. Therefore, treatment customization for…